I have just skimmed through the thread, and it definitely rings some bells. I had the very same issue on my old gen Scarlett 2i4. Is your device an old gen?
EVD wrote:Thanks. Yeah well, your conclusions are logical, however I can't accept it to be broken.
There is something fishy about that +48V button, on the old gen. It killed 2 devices for me. I wrote about it here:
https://thecrocoduckspond.wordpress.com ... st-review/