Rather surprisingly, I have been able to get Yousician to run under Wine on AV Linux MX Edition, with WineASIO inputs appearing in Qjackctl. It's glitchy, but as long as the Yousician window doesn't go out of focus it seems stable. Problem is, audio routed to the WineASIO inputs in Wine doesn't really get to Yousician. I tried the Windows version of Reaper, same deal.
Is there any way to get WineASIO working on AVL-MXE?
And just in case I can forgo Wine altogether: is there any software like Yousician / Rocksmith with real-time feedback that runs (semi-)natively and glitch-free on AVL-MXE?